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10-OH-HHCP: Everything you need to know

What is 10-OH-HHCP and how was it born?

10-OH-HHCP (10-hydroxy-hexahydrocannabichol), a modified version of HHCP (hexahydrocannabichol), is born in the laboratory. HHCP is produced from hexahydrocannabinol (HHC), which is found in the cannabis plant but is more commonly produced from more readily available precursors such as CBD or terpenes.

And how is 10-OH-HHCP produced? This cannabinoid is produced by the oxidation of HHCP, which is handled by the enzyme cytochrome P450, found mainly in the liver. In this chemical process, a hydroxyl group (-OH) is added to the 10th position of the HHCP molecule. What is this hydroxyl group? Simply put, it is 1 molecule of oxygen that is covalently bonded to 1 molecule of hydrogen.

This is all science in action, the starting compound undergoes an "upgrade" and as this process increases the solubility of the substance, one would expect the interaction with receptors in the body to change and therefore the effects.

 

10-OH-HHCP distillate production concept

Effects of 10-OH-HHCP

It is currently unclear how 10-OH-HHCP acts in the body. In general, it is reported to have an effective binding to CB1 receptors (mainly in the brain) in the endocannabinoid system (ECS) and therefore produces psychoactive effects.

However, we lack detailed information on exactly how 10-OH-HHCP interacts with receptors in the ECS and what effects it has.

At the moment, the findings with other psychoactive cannabinoids such as THC, HHC, HHCP or THCB can be used. 10-OH-HHCP can therefore affect perception, induce feelings of euphoria, relaxation or increase appetite.

The way 10-OH-HHCP is taken also affects its effects. Oral administration of this substance can lead to the formation of more inactive metabolites compared to vaping or sublingual administration (dripping under the tongue).

How is 10-OH-HHCP metabolized?

10-OH-HHCP can be processed (metabolized) in the liver by cytochrome P450 enzymes, similar to other cannabinoid hydroxyderivatives. However, there are currently no detailed studies on the specific metabolic pathways through which it passes and exactly what metabolites are produced.

In May 2024, a study on HHC was released, which investigated how this cannabinoid is metabolised in human liver cells (hepatocytes). The study aimed to identify specific metabolites produced during metabolisation and determine how quickly these compounds are eliminated from the body.

The study revealed that HHC is metabolized in hepatocytes through various metabolic pathways, including oxidation and conjugation. Conjugation is a biochemical process in which small molecules (glucuronide, sulphate, glycine or glutathione) are attached to the metabolised compounds. These molecules increase the solubility of the compounds in water and facilitate their excretion from the body.

It can be assumed that 10-OH-HHCP has a low bioavailability and undergoes rapid metabolic breakdown in the body and has a short half-life. The half-life is the time during which the concentration of a cannabinoid in the blood is halved due to metabolism and excretion.

Side effects of 10-OH-HHCP

Still, we don't have any studies available, so we will draw on experience with other psychoactive cannabinoids.

How intensely side effects occur depends on several factors such as age, body proportions, individual health, metabolism and sensitivity of the user, dose size and route of administration.

Possible side effects include:

 

A man has a headache, which may be a side effect of 10-OH-HHCP

Comparison table: 10-OH-HHCP vs. HHCP vs. 10-OH-HHC vs. HHC

The following table provides a basic comparison of 10-OH-HHCP, HHCP, 10-OH-HHC and HHC compounds.

 

10-OH-HHCP

HHCP

10-OH-HHC

HHC

Occurrence in cannabis

No

No

No

Yes, only in trace amounts.

Specifications

A derivative of HHCP with an added hydroxyl group (-OH) at the 10th carbon.

A semi-synthetic cannabinoid; derived from HHC, 7-carbon alkyl side chain.

A derivative of HHC with an added hydroxyl group (-OH) at the 10th carbon.

A semi-synthetic cannabinoid; originally a derivative of THC, it is now more commonly produced synthetically by hydrogenation of CBD. It is formed by the addition of hydrogen molecules.

Psychoactive properties

Yes

Yes

Yes

Yes

Possible effects
  • Euphoria
  •  promoting relaxation
  • increased appetite
  • Euphoria
  • relief from stress and anxiety
  • Release
  • better sleep
  • increased appetite

 
  •  Euphoria
  •  promoting relaxation
  •  increased appetite
  •  Euphoria
  • more energy
  •  promoting relaxation
  •  improving sleep

Legal status

Ambiguous, in most countries in a legal grey area

A substance already banned in most European countries

Ambiguous, in most countries in a legal grey area

A substance already banned in most European countries

10-OH-HHCP products: what is their range, safety and legality?

The market offers a wide range of products containing 10-OH-HHCP, despite the lack of research on effects and safety. It is therefore up to users to weigh up the potential risks and benefits of these substances. Until cannabis extracts and derivatives are regulated, it is not possible to ensure their quality, safety and legality across the board.

If you want to buy any cannabis product, rely on established and trusted companies that have their products verified by an independent third party (laboratory).

If the product lacks a laboratory analysis, contact the seller and ask for one. This is important to get information about what the product contains and whether there are any unsuitable ingredients, fillers and toxins.

Third-party laboratory reports shall contain objective data on the composition, purity of the product and an indication of whether the THC maximum limit is exceeded. In the Czech Republic, the maximum THC limit is 1 %, in Europe 0,2-0,3 % THC on a dry basis.

This brings us to the legality of 10-OH-HHCP products. Despite marijuana remaining illegal and stigmatised in many parts of the world for decades, the US Farm Bill removed cannabis with up to 0.3% THC from the list of controlled substances, thereby legalising cannabis derivatives that meet this condition.

In general, products with less than 0,2 % THC are generally sold on the market and are therefore considered legal. However, the legal status of 10-OH-HHCP remains unclear for the time being and may fall into a legal grey area in many countries.

Commonly available 10-OH-HHCP products include:

  • Vapes: allow vaporisation of a substance in the form of vapour; these are either disposable vape pens or devices that are refillable or with replaceable cartridges
  • Cartridge: pre-filled cartridges with 10-OH-HHCP liquid
  • Liquids: liquids intended for vaporisation
  • 10-OH-HHCP flowers: cannabis flowers (buds) from industrial hemp infused with 10-OH-HHCP distillate
  • Pre-rolls: pre-packaged joints that are already filled with treated flowers
  • Hash: cannabis concentrate
  • Gummies: gelatine candies enriched with 10-OH-HHCP

Never drive or operate any machinery after taking similar compounds.

Canntropy cartridge 10-OH-HHCP Lime Diesel

Conclusion

In today's article, we have found that 10-OH-HHCP is a hydroxy derivative of HHCP and that it is formed in a rather interesting way - by oxidation of HHCP with the help of the liver enzyme cytochrome P450, whereby a hydroxyl group (-OH) is attached to the 10th position of the hexahydrocannabiphoryl nucleus.

As far as research goes, we don't have enough information yet. It is still the case that scientists have not investigated at all how 10-OH-HHCP works in the body and what its safety is.

Since it is a hydroxy derivative, we can expect that it will not stay in the body for very long. This is because these substances have low bioavailability and break down quickly - the body processes and eliminates them quickly.

Remember that (semi)synthetic compounds can be tricky, as they are much more potent than natural cannabinoids. This increases the chance of intoxication or overdose, which can lead to a so-called bad trip.

It is good to remember that even what sounds appealing has its risks. So, as they say: everything in moderation! 😊

 

Author: Buds for Buddies

 

   

Photo: Shutterstock

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